HEPDONE

High-Throughput Evolution Platform for Discovery and Optimization of Novel Editors (HEPDONETM)

1.AI-Powered Discovery Platform using Metagenomics Data
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2.lterative High-Throughput Screening and Enzyme Engineering
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  • 50
    TB

    Base pairs

  • 311
    K

    Samples

  • 21
    B

    Proteins

  • 1
    M

    Cas

  • >
    100
    K

    CRISPR-Cas loci

Core Advantages of HEPDONETM

  • Al-assisted rational design

  • Random mutagenesis

  • The screening throughput reaches 10 billion+ per round,which can screen candidate editors with higher editing efficiency and different editing windows

  • “Eukaryotic-prokaryotic” shuttle screening, greatly improving validation efficiency

  • 2-3 rounds per week

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With our High-Throughput Direct Evolution Platform for Discovery and Optimization of Novel Editors (HEPDONE?), we have developed proprietary genome editing toolkits and multiple editing strategies, Our main focus has been on Base Editor that can insert, delete and replace DNA in highly precise manner ( to only edit intended DNA targets and avoid off-target editing) without causing a double-stranded break. Additionally, our guide RNA sequences can be designed to specifically target desired DNA or RNA sequences, reducing the risk of unintended changes to other genes and minimizing off-target effects.

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